| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 640 | $343.79K |
| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 505 | $272.8K |
| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 644 | $344.72K |
| Fri, 11 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 218 | $116.84K |
| Fri, 11 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 1,539 | $837.25K |
| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 215 | $115.89K |
| Fri, 11 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 60 | $31.99K |
| Fri, 11 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 106 | $56.61K |
| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 1,040 | $557.56K |
| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 522 | $276.78K |
| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 131 | $69.15K |
| Fri, 11 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 120 | $65.57K |
| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 520 | $279.91K |
| Fri, 11 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 160 | $86.02K |
| Fri, 11 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 1,202 | $652.21K |
| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 368 | $195.77K |
| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 512 | $272.94K |
| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 396 | $211.54K |
| Fri, 11 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 368 | $199.32K |
| Fri, 11 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 761 | $414.62K |
| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 347 | $183.66K |
| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 160 | $86.81K |
| Fri, 11 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 687 | $371.38K |
| Wed, 9 Sep 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 362 | $196.08K |
| Mon, 17 Aug 2026 | Kelley Shannon T | officer: General Counsel | S-Sale | 664 | $341.94K |
| Sat, 15 Aug 2026 | REED JOHN C | director | A-Award | 1,078 | $547.15K |
| Tue, 11 Aug 2026 | REED JOHN C | director: | — | 0 | $0 |
| Sat, 15 Aug 2026 | REED JOHN C | director | A-Award | 647 | $0 |
| Sat, 15 Aug 2026 | REED JOHN C | director | A-Award | 647 | $0 |
| Mon, 20 Jul 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 1 | $550.72 |
| Mon, 20 Jul 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 153 | $84.15K |
| Mon, 20 Jul 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 280 | $155.41K |
| Fri, 17 Jul 2026 | Sibold William John | director, officer: President and CEO | M-Exempt | 50,000 | — |
| Mon, 20 Jul 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 110 | $59.82K |
| Mon, 20 Jul 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 545 | $296.87K |
| Mon, 20 Jul 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 275 | $150.07K |
| Mon, 20 Jul 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 269 | $147.16K |
| Mon, 20 Jul 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 140 | $75.98K |
| Mon, 20 Jul 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 680 | $372.43K |
| Mon, 20 Jul 2026 | Sibold William John | director, officer: President and CEO | S-Sale | 47 | $25.8K |
| Wed, 17 Jun 2026 | FOUSE JACQUALYN A | director | A-Award | 454 | $0 |
| Wed, 17 Jun 2026 | Levy Richard S | director | A-Award | 454 | $0 |
| Wed, 17 Jun 2026 | Daly James M | director | A-Award | 454 | $0 |
| Wed, 17 Jun 2026 | Brennan Daniel J. | director | A-Award | 404 | $0 |
| Wed, 17 Jun 2026 | Baker Brothers Life Sciences LP | director | A-Award | 908 | $0 |
| Wed, 17 Jun 2026 | Taub Rebecca | director | A-Award | 454 | $0 |
| Mon, 1 Jun 2026 | Soergel David | officer: Chief Medical Officer | S-Sale | 1,042 | $516.56K |
| Fri, 22 May 2026 | Levy Richard S | director | S-Sale | 40 | $20.27K |
| Fri, 22 May 2026 | Levy Richard S | director | S-Sale | 320 | $162.64K |
| Fri, 22 May 2026 | Levy Richard S | director | S-Sale | 657 | $338.96K |
