| Holder | Shares | % out | Change |
|---|---|---|---|
| Vivo Capital, LLC | 5,903,000 | 8.2% | +0 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,430 | 0.0% | +0 |
| MORGAN STANLEY | 9,146 | 0.0% | +2 |
| WELLS FARGO & COMPANY/MN | 4,580 | 0.0% | −231 |
| UBS Group AG | 2,479 | 0.0% | +250 |
| HARBOUR INVESTMENTS, INC. | 78 | 0.0% | −5 |
| Horizon Investments, LLC | 52 | 0.0% | −52 |