| Boxer Capital Management, LLC | 560,000 | 4.9% | — |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 414,958 | 3.6% | +272,489 |
| Bleichroeder LP | 400,000 | 3.5% | +0 |
| Ikarian Capital, LLC | 396,201 | 3.5% | — |
| Dauntless Investment Group, LLC | 354,208 | 3.1% | +274,376 |
| Stonepine Capital Management, LLC | 345,179 | 3.0% | +0 |
| Point72 Asset Management, L.P. | 200,300 | 1.8% | +300 |
| Ensign Peak Advisors, Inc | 110,778 | 1.0% | — |
| MILLENNIUM MANAGEMENT LLC | 101,376 | 0.9% | — |
| UBS Group AG | 81,090 | 0.7% | +67,156 |
| J. Goldman & Co LP | 68,491 | 0.6% | — |
| ADAR1 Capital Management, LLC | 61,550 | 0.5% | — |
| JANE STREET GROUP, LLC | 57,140 | 0.5% | — |
| BARCLAYS PLC | 56,999 | 0.5% | +33,000 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,616 | 0.4% | — |