| Caligan Partners LP | 8,163,191 | 3.4% | +3,188,285 |
| SAMSARA BIOCAPITAL, LLC | 6,314,805 | 2.7% | +1,120,000 |
| Paradigm Biocapital Advisors LP | 4,000,000 | 1.7% | +0 |
| ANDERA PARTNERS | 3,633,181 | 1.5% | +1,815,000 |
| ADAR1 Capital Management, LLC | 3,606,656 | 1.5% | +1,432,258 |
| MILLENNIUM MANAGEMENT LLC | 3,512,174 | 1.5% | +524,561 |
| Nantahala Capital Management, LLC | 2,686,393 | 1.1% | — |
| Trails Edge Capital Partners, LP | 2,657,997 | 1.1% | +0 |
| FRANKLIN RESOURCES INC | 2,642,611 | 1.1% | +181,046 |
| Squadron Capital Management LLC | 2,435,000 | 1.0% | +1,900,000 |
| Woodline Partners LP | 2,323,149 | 1.0% | — |
| Aberdeen Group plc | 2,307,773 | 1.0% | — |
| UBS Group AG | 2,305,192 | 1.0% | −13,501 |
| BOOTHBAY FUND MANAGEMENT, LLC | 2,003,782 | 0.8% | +533,375 |
| Patient Square Capital LP | 1,967,171 | 0.8% | — |