| Date | Name | Role | Type | Shares | Value |
|---|---|---|---|---|---|
| Wed, 26 Aug 2026 | PERCEPTIVE ADVISORS LLC | director | P-Purchase | 863,060 | $7.5M |
| Wed, 26 Aug 2026 | EDELMAN JOSEPH | director | P-Purchase | 863,060 | $7.5M |
| Fri, 14 Aug 2026 | Pepin James Nelson | officer: Gen Counsel and Corp Secretary | A-Award | 181,200 | $1.71M |
| Fri, 14 Aug 2026 | Pepin James Nelson | officer: Gen Counsel and Corp Secretary | A-Award | 43,800 | $0 |
| Holder | Shares | % out | Change |
|---|---|---|---|
| RTW INVESTMENTS, LP | 12,946,176 | 8.7% | +76,836 |
| MONTANOVA CAPITAL, LLC | 11,190,129 | 7.5% | +0 |
| PERCEPTIVE ADVISORS LLC |
| 10,383,456 |
| 6.9% |
| +0 |
| BAKER BROS. ADVISORS LP | 9,508,565 | 6.4% | −1,408,128 |
| Jefferies Financial Group Inc. | 6,506,802 | 4.3% | +1,447,251 |
| Vestal Point Capital, LP | 6,175,000 | 4.1% | +0 |
| Sofinnova Investments, Inc. | 3,669,346 | 2.5% | +38,892 |
| MORGAN STANLEY | 2,186,494 | 1.5% | +37,412 |
| CITADEL ADVISORS LLC | 1,814,657 | 1.2% | −37,306 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,647,852 | 1.1% | +85,960 |
| Point72 Asset Management, L.P. | 1,449,597 | 1.0% | −44,203 |
| Woodline Partners LP | 900,736 | 0.6% | −99,861 |
| SPHERA FUNDS MANAGEMENT LTD. | 720,057 | 0.5% | +23,952 |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | 0.5% | +0 |
| Aberdeen Group plc | 653,604 | 0.4% | −167,113 |
