| Affinity Asset Advisors, LLC | 4,007,881 | 6.6% | +900,681 |
| Cormorant Asset Management, LP | 3,570,000 | 5.9% | — |
| SILVERARC CAPITAL MANAGEMENT, LLC | 3,520,490 | 5.8% | +3,294,490 |
| Vestal Point Capital, LP | 2,600,000 | 4.3% | — |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,098,151 | 3.4% | +1,009,852 |
| Frazier Life Sciences Management, L.P. | 1,953,467 | 3.2% | +0 |
| Ensign Peak Advisors, Inc | 1,832,457 | 3.0% | — |
| Woodline Partners LP | 1,776,547 | 2.9% | — |
| MILLENNIUM MANAGEMENT LLC | 1,651,473 | 2.7% | +101,623 |
| CITADEL ADVISORS LLC | 1,384,029 | 2.3% | +427,600 |
| Balyasny Asset Management L.P. | 1,170,893 | 1.9% | +159,938 |
| BANK OF AMERICA CORP /DE/ | 1,121,492 | 1.8% | +831,079 |
| Ikarian Capital, LLC | 957,062 | 1.6% | +0 |
| Sio Capital Management, LLC | 904,268 | 1.5% | +0 |
| MARSHALL WACE, LLP | 904,132 | 1.5% | +283,530 |
