| Fri, 14 Aug 2026 | Shojaei Amir | officer: CHIEF SCIENTIFIC OFFICER | M-Exempt | 11,250 | $404.55K |
| Fri, 14 Aug 2026 | Shojaei Amir | officer: CHIEF SCIENTIFIC OFFICER | S-Sale | 11,250 | $450K |
| Fri, 14 Aug 2026 | Shojaei Amir | officer: CHIEF SCIENTIFIC OFFICER | S-Sale | 11,250 | $450K |
| Fri, 14 Aug 2026 | Shojaei Amir | officer: CHIEF SCIENTIFIC OFFICER | M-Exempt | 11,250 | $404.55K |
| Mon, 18 May 2026 | SILVERNAIL LAUREN P | director | P-Purchase | 1,000 | $31K |
| Mon, 18 May 2026 | Graves Adrienne L | director | P-Purchase | 1,000 | $31.07K |
| Thu, 14 May 2026 | BOLL ANDREW R. | officer: PRESIDENT AND CFO | P-Purchase | 3,500 | $104.65K |
| Thu, 14 May 2026 | BAUM MARK L | director, officer: CHIEF EXECUTIVE OFFICER | P-Purchase | 10,000 | $302K |
| Wed, 4 Mar 2026 | Opaleye Management Inc. | 10 percent owner | S-Sale | 4,263 | $169.11K |
| Wed, 4 Mar 2026 | Opaleye Management Inc. | 10 percent owner | S-Sale | 134,000 | $5.32M |
| Tue, 3 Mar 2026 | Opaleye Management Inc. | 10 percent owner | S-Sale | 59,000 | $2.31M |
| Tue, 3 Mar 2026 | Opaleye Management Inc. | 10 percent owner | S-Sale | 1,309 | $51.25K |
| Fri, 27 Feb 2026 | Opaleye Management Inc. | 10 percent owner | S-Sale | 5,000 | $270.9K |
| Tue, 6 Jan 2026 | Opaleye Management Inc. | 10 percent owner | S-Sale | 20,000 | $1.07M |
| Fri, 12 Dec 2025 | BAUM MARK L | director, officer: CHIEF EXECUTIVE OFFICER | M-Exempt | 180,000 | $711K |
| Fri, 12 Dec 2025 | BAUM MARK L | director, officer: CHIEF EXECUTIVE OFFICER | F-InKind | 79,994 | $3.76M |
| Fri, 12 Dec 2025 | BOLL ANDREW R. | officer: PRESIDENT AND CFO | F-InKind | 26,665 | $1.25M |
| Fri, 12 Dec 2025 | BOLL ANDREW R. | officer: PRESIDENT AND CFO | M-Exempt | 60,000 | $237K |
