| Holder | Shares | % out | Change |
|---|---|---|---|
| Paradigm Biocapital Advisors LP | 13,133,131 | 2.2% | +5,165,295 |
| Orbis Allan Gray Ltd | 11,368,161 | 1.9% | −1,557,417 |
| ALLIANCEBERNSTEIN L.P. | 8,644,877 | 1.4% | −912,272 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 6,865,000 | 1.1% | +4,403,000 |
| Deep Track Capital, LP | 5,650,000 | 0.9% | +1,986,750 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 4,975,324 | 0.8% | +0 |
| BlackRock, Inc. | 4,671,252 | 0.8% | +134,687 |
| Sofinnova Investments, Inc. | 4,045,215 | 0.7% | +3,292,954 |
| Renaissance Technologies | 3,517,850 | 0.6% | — |
| RENAISSANCE TECHNOLOGIES LLC | 3,517,850 | 0.6% | −896,700 |
| TWO SIGMA INVESTMENTS, LP | 3,506,843 | 0.6% | +1,167,411 |
| Harding Loevner LP | 3,086,318 | 0.5% | −145,283 |
| FIRST TRUST ADVISORS LP | 2,756,522 | 0.5% | +295,180 |
| CITADEL ADVISORS LLC | 2,475,991 | 0.4% | — |
| Qube Research & Technologies Ltd | 1,689,284 | 0.3% | +1,011,938 |