| Date | Name | Role | Type | Shares | Value |
|---|---|---|---|---|---|
| Mon, 12 Oct 2026 | Evans Terry L | officer: Chief Commercial Officer | A-Award | 2,326 | $12.86K |
| Mon, 12 Oct 2026 | Sayad Pierre Sargis | officer: Chief Medical Officer | A-Award | 3,846 | $21.27K |
| Mon, 12 Oct 2026 | Hackman Jeffrey S. | director, officer: Chief Executive Officer | A-Award | 2,224 | $12.3K |
| Mon, 12 Oct 2026 | Cioffi Christiana Marie | officer: Chief Strategy Officer | A-Award | 3,946 | $21.82K |
| Mon, 12 Oct 2026 | Andrade Robert | officer: CHIEF FINANCIAL OFFICER | A-Award | 3,846 | $21.27K |
| Wed, 30 Sep 2026 | Cioffi Christiana Marie | officer: Chief Strategy Officer | A-Award | 156 | $0 |
| Wed, 30 Sep 2026 | Evans Terry L | officer: Chief Commercial Officer | A-Award | 168 | $0 |
| Wed, 30 Sep 2026 | Sayad Pierre Sargis | officer: Chief Medical Officer | A-Award | 168 | $0 |
| Wed, 30 Sep 2026 | Andrade Robert | officer: CHIEF FINANCIAL OFFICER | A-Award | 1,703 | $0 |
| Wed, 30 Sep 2026 | Hackman Jeffrey S. | director, officer: Chief Executive Officer | A-Award | 1,159 | $0 |
| Tue, 15 Sep 2026 | Brughera Marco Maria | director | S-Sale | 15,545 | $159.96K |
| Tue, 15 Sep 2026 | Brughera Marco Maria | director | M-Exempt | 15,545 | $32.8K |
| Tue, 1 Sep 2026 | Raykov Rosty | other | S-Sale | 10,000 | $121.1K |
| Mon, 31 Aug 2026 | Raykov Rosty | other | A-Award | 2,778 | $0 |
| Mon, 31 Aug 2026 | Hackman Jeffrey S. | director, officer: Chief Executive Officer | A-Award | 1,159 | $0 |
| Mon, 31 Aug 2026 | Andrade Robert | officer: CHIEF FINANCIAL OFFICER | A-Award | 1,703 | $0 |
| Mon, 31 Aug 2026 | Evans Terry L | officer: Chief Commercial Officer | A-Award | 168 | $0 |
| Mon, 31 Aug 2026 | Sayad Pierre Sargis | officer: Chief Medical Officer | A-Award | 168 | $0 |
| Mon, 31 Aug 2026 | Cioffi Christiana Marie | officer: Chief Strategy Officer | A-Award | 156 | $0 |
| Mon, 31 Aug 2026 | Sayad Pierre Sargis | officer: Chief Medical Officer | S-Sale | 12,000 | $146.16K |
| Thu, 27 Aug 2026 | Andrade Robert | officer: CHIEF FINANCIAL OFFICER | S-Sale | 75,000 | $883.5K |
| Fri, 28 Aug 2026 | Andrade Robert | officer: CHIEF FINANCIAL OFFICER | M-Exempt | 21,928 | $111.83K |
| Mon, 3 Aug 2026 | Raykov Rosty | other | S-Sale | 10,000 | $95.8K |
| Fri, 31 Jul 2026 | Raykov Rosty | other | A-Award | 2,778 | $0 |
| Fri, 31 Jul 2026 | Cioffi Christiana Marie | officer: Chief Strategy Officer | A-Award | 156 | $0 |
| Fri, 31 Jul 2026 | Andrade Robert | officer: CHIEF FINANCIAL OFFICER | A-Award | 1,703 | $0 |
| Fri, 31 Jul 2026 | Evans Terry L | officer: Chief Commercial Officer | A-Award | 168 | $0 |
| Fri, 31 Jul 2026 | Hackman Jeffrey S. | director, officer: Chief Executive Officer | A-Award | 1,159 | $0 |
| Fri, 31 Jul 2026 | Sayad Pierre Sargis | officer: Chief Medical Officer | A-Award | 168 | $0 |
| Wed, 1 Jul 2026 | Raykov Rosty | other | M-Exempt | 15,597 | $38.21K |
| Wed, 1 Jul 2026 | Raykov Rosty | other | S-Sale | 9,599 | $99.93K |
| Wed, 1 Jul 2026 | Raykov Rosty | other | A-Award | 2,778 | $0 |
| Tue, 30 Jun 2026 | Evans Terry L | officer: Chief Commercial Officer | A-Award | 168 | $0 |
| Tue, 30 Jun 2026 | Cioffi Christiana Marie | officer: Chief Strategy Officer | A-Award | 156 | $0 |
| Tue, 30 Jun 2026 | Hackman Jeffrey S. | director, officer: Chief Executive Officer | A-Award | 1,159 | $0 |
| Tue, 30 Jun 2026 | Andrade Robert | officer: CHIEF FINANCIAL OFFICER | A-Award | 1,703 | $0 |
| Tue, 30 Jun 2026 | Sayad Pierre Sargis | officer: Chief Medical Officer | A-Award | 168 | $0 |
| Sun, 31 May 2026 | Raykov Rosty | director | A-Award | 2,778 | $0 |
| Mon, 1 Jun 2026 | Raykov Rosty | director | S-Sale | 9,747 | $93.77K |
| Mon, 1 Jun 2026 | Raykov Rosty | director | M-Exempt | 15,597 | $38.21K |
| Sun, 31 May 2026 | Sayad Pierre Sargis | officer: Chief Medical Officer | A-Award | 168 | $0 |
| Sun, 31 May 2026 | Evans Terry L | officer: Chief Commercial Officer | A-Award | 168 | $0 |
| Sun, 31 May 2026 | Cioffi Christiana Marie | officer: Chief Strategy Officer | A-Award | 156 | $0 |
| Sun, 31 May 2026 | Hackman Jeffrey S. | director, officer: Chief Executive Officer | A-Award | 1,159 | $0 |
| Sun, 31 May 2026 | Andrade Robert | officer: CHIEF FINANCIAL OFFICER | A-Award | 1,703 | $0 |
| Mon, 11 May 2026 | RALLIS CHRIS A | director | S-Sale | 8,346 | $58.76K |
| Mon, 11 May 2026 | RALLIS CHRIS A | director | M-Exempt | 14,344 | $35K |
| Thu, 30 Apr 2026 | Andrade Robert | officer: CHIEF FINANCIAL OFFICER | M-Exempt | 1,703 | $0 |
| Fri, 1 May 2026 | Raykov Rosty | director | S-Sale | 10,781 | $69.75K |
| Fri, 1 May 2026 | Raykov Rosty | director | M-Exempt | 15,598 | $38.22K |
| Holder | Shares | % out | Change |
|---|---|---|---|
| Rosalind Advisors, Inc. | 3,188,001 | 9.1% | +279,800 |
| AIGH Capital Management LLC | 2,486,038 | 7.1% | +504,537 |
| Solas Capital Management, LLC | 1,889,366 | 5.4% | −592,832 |
| BlackRock, Inc. | 1,727,069 | 4.9% | +358,893 |
| AWM Investment Company, Inc. | 1,160,296 | 3.3% | +440,161 |
| VANGUARD CAPITAL MANAGEMENT LLC | 839,306 | 2.4% | −57,838 |
| Prospect Capital Advisors, LLC | 497,800 | 1.4% | — |
| STATE STREET CORP | 426,004 | 1.2% | +66,949 |
| GEODE CAPITAL MANAGEMENT, LLC | 402,566 | 1.1% | +30,828 |
| JANE STREET GROUP, LLC | 233,877 | 0.7% | — |
| Potomac Capital Management, Inc. | 224,400 | 0.6% | +0 |
| MORGAN STANLEY | 221,920 | 0.6% | +10,812 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 199,998 | 0.6% | +31,525 |
| NORTHERN TRUST CORP |
| 167,922 |
| 0.5% |
| +15,799 |
| MARSHALL WACE, LLP | 138,758 | 0.4% | — |
