| Date | Name | Role | Type | Shares | Value |
|---|---|---|---|---|---|
| Tue, 1 Sep 2026 | Person Julie | officer: Chief People Officer | A-Award | 107,611 | $0 |
| Tue, 1 Sep 2026 | Hopkins Janet Jill | officer: Chief Medical Officer | A-Award | 58,850 | $0 |
| Tue, 1 Sep 2026 | Elazzouzi Amy | officer: SVP, Finance & PAO | A-Award | 23,540 | $0 |
| Tue, 1 Sep 2026 | Abu-Absi Susan | officer: Chief Operating Officer | A-Award | 134,513 | $0 |
| Tue, 1 Sep 2026 | Kratz Erica | officer: Chief Reg. & Quality Officer | A-Award | 100,885 | $0 |
| Wed, 12 Aug 2026 | Person Julie | — | — | 0 | $0 |
| Mon, 10 Aug 2026 | Kratz Erica | — | — | 0 |
| $0 |
| Mon, 10 Aug 2026 | Abu-Absi Susan | — | — | 0 | $0 |
| Tue, 7 Jul 2026 | Bender Jeremy | director | A-Award | 30,000 | $0 |
| Wed, 1 Jul 2026 | Kilroy Conor | officer: See Remarks | A-Award | 14,858 | $0 |
| Tue, 16 Jun 2026 | Gibney Anthony S | officer: See Remarks | S-Sale | 12,824 | $82.33K |
| Thu, 11 Jun 2026 | Mattessich Antony C. | director | A-Award | 15,000 | $0 |
| Thu, 11 Jun 2026 | Johnson David Michael | director | A-Award | 15,000 | $0 |
| Thu, 11 Jun 2026 | Srivastava Sapna | director | A-Award | 15,000 | $0 |
| Thu, 11 Jun 2026 | Bitetti Teresa Marie | director | A-Award | 15,000 | $0 |
| Tue, 19 May 2026 | Holles Natalie C. | director, officer: See Remarks | A-Award | 553,844 | $0 |
| Tue, 19 May 2026 | Holles Natalie C. | director, officer: See Remarks | A-Award | 600,118 | $0 |
| Thu, 7 May 2026 | Matrix Capital Management Company, LP | 10 percent owner | S-Sale | 6,922,870 | $39.04M |
| Thu, 16 Apr 2026 | Kilroy Conor | officer: See Remarks | S-Sale | 11,738 | $82.4K |
| Mon, 2 Mar 2026 | Elazzouzi Amy | officer: Senior Vice President, Finance | A-Award | 44,528 | $0 |
| Mon, 2 Mar 2026 | Hopkins Janet Jill | officer: Chief Medical Officer | A-Award | 89,056 | $0 |
| Mon, 2 Mar 2026 | Plavsic Mark | officer: Chief Technology Officer | A-Award | 62,339 | $0 |
| Mon, 2 Mar 2026 | de los Pinos Elisabet | director, officer: See Remarks | A-Award | 166,000 | $0 |
| Mon, 2 Mar 2026 | Gibney Anthony S | officer: See Remarks | A-Award | 71,245 | $0 |
| Mon, 2 Mar 2026 | Kilroy Conor | officer: See Remarks | A-Award | 62,339 | $0 |
| Tue, 17 Feb 2026 | de los Pinos Elisabet | director, officer: See Remarks | S-Sale | 47,648 | $241.1K |
| Tue, 17 Feb 2026 | Elazzouzi Amy | officer: Senior Vice President, Finance | S-Sale | 8,549 | $43.26K |
| Tue, 17 Feb 2026 | Hopkins Janet Jill | officer: Chief Medical Officer | S-Sale | 20,401 | $103.23K |
| Tue, 17 Feb 2026 | Plavsic Mark | officer: Chief Technology Officer | S-Sale | 15,890 | $80.24K |
| Tue, 17 Feb 2026 | Kilroy Conor | officer: See Remarks | S-Sale | 12,079 | $61K |
| Tue, 20 Jan 2026 | de los Pinos Elisabet | director, officer: See Remarks | S-Sale | 16,928 | $82.27K |
| Tue, 20 Jan 2026 | Elazzouzi Amy | officer: Senior Vice President, Finance | S-Sale | 1,581 | $7.68K |
| Mon, 17 Nov 2025 | Hopkins Janet Jill | officer: Chief Medical Officer | S-Sale | 17,109 | $92.73K |
| Wed, 29 Oct 2025 | de los Pinos Elisabet | director, officer: See Remarks | S-Sale | 9,049 | $57.46K |
| Wed, 29 Oct 2025 | Elazzouzi Amy | officer: Senior Vice President, Finance | S-Sale | 896 | $5.69K |
| Holder | Shares | % out | Change |
|---|---|---|---|
| TCG Crossover Management, LLC | 9,533,333 | 9.2% | — |
| MONTANOVA CAPITAL, LLC | 7,206,217 | 6.9% | +2,833,333 |
| Frazier Life Sciences Management, L.P. | 7,100,000 | 6.8% | +2,000,000 |
| Long Focus Capital Management, LLC | 5,119,582 | 4.9% | +500,000 |
| BlackRock, Inc. | 4,707,674 | 4.5% | +1,121,034 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,640,000 | 4.5% | −241,125 |
| Caligan Partners LP | 4,298,248 | 4.1% | +4,068,384 |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,100,342 | 4.0% | +1,856,514 |
| FCPM III SERVICES B.V. | 4,053,775 | 3.9% | — |
| ORBIMED ADVISORS LLC | 3,333,333 | 3.2% | — |
| Medicxi Ventures Management (Jersey) Ltd | 3,039,892 | 2.9% | +0 |
| Nantahala Capital Management, LLC | 2,951,030 | 2.8% | +833,333 |
| Jupiter Topco LLC | 2,500,000 | 2.4% | — |
| RA CAPITAL MANAGEMENT, L.P. | 2,500,000 | 2.4% | — |
| Balyasny Asset Management L.P. | 2,354,619 | 2.3% | +1,796,965 |
