| Date | Name | Role | Type | Shares | Value |
|---|---|---|---|---|---|
| Wed, 17 Jun 2026 | Porter Derrell | director | M-Exempt | 13,040 | $13.95K |
| Wed, 17 Jun 2026 | Porter Derrell | director | S-Sale | 13,040 | $30.38K |
| Tue, 16 Jun 2026 | Porter Derrell | director | S-Sale | 12,800 | $29.82K |
| Mon, 15 Jun 2026 | Porter Derrell | director | M-Exempt | 6,460 | $6.91K |
| Mon, 15 Jun 2026 | Porter Derrell | director | S-Sale | 6,460 | $15.18K |
| Tue, 9 Jun 2026 | Fountain Nathan B | director | S-Sale | 6,400 | $14.27K |
| Wed, 3 Jun 2026 | RA Capital Nexus Fund II, L.P. | director | A-Award |
| 35,500 |
| $0 |
| Wed, 3 Jun 2026 | Stoppel Laura | director | A-Award | 35,500 | $0 |
| Wed, 3 Jun 2026 | Golumbeski George | director | A-Award | 35,500 | $0 |
| Wed, 3 Jun 2026 | Ives Jeffrey L. | director | A-Award | 35,500 | $0 |
| Wed, 3 Jun 2026 | Porter Derrell | director | A-Award | 35,500 | $0 |
| Wed, 3 Jun 2026 | Stalfort John A III | director | A-Award | 35,500 | $0 |
| Wed, 3 Jun 2026 | Drapkin Kimberlee C | director | A-Award | 35,500 | $0 |
| Wed, 3 Jun 2026 | Fountain Nathan B | director | A-Award | 35,500 | $0 |
| Mon, 16 Mar 2026 | Shah Rajeev M. | director, 10 percent owner | A-Award | 6,060,606 | $20M |
| Fri, 6 Mar 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | S-Sale | 2,090 | $6.81K |
| Fri, 6 Mar 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | M-Exempt | 2,090 | $3.87K |
| Fri, 27 Feb 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | S-Sale | 9,406 | $28.31K |
| Fri, 27 Feb 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | M-Exempt | 9,406 | $17.4K |
| Wed, 28 Jan 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | S-Sale | 2,671 | $8.01K |
| Wed, 28 Jan 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | M-Exempt | 2,671 | $4.94K |
| Mon, 26 Jan 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | M-Exempt | 15,085 | $27.91K |
| Mon, 26 Jan 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | S-Sale | 15,085 | $45.26K |
| Fri, 23 Jan 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | S-Sale | 5,633 | $10.7K |
| Thu, 22 Jan 2026 | Barton Russell | officer: Chief Operating Officer | S-Sale | 462 | $850.08 |
| Thu, 22 Jan 2026 | OConnell Daniel Joseph | director, officer: Chief Executive Officer | S-Sale | 2,689 | $5.06K |
| Thu, 22 Jan 2026 | Zuga Matt | officer: CFO & Chief Business Officer | S-Sale | 1,687 | $3.14K |
| Thu, 22 Jan 2026 | Siemers Eric | officer: Chief Medical Officer | S-Sale | 895 | $1.63K |
| Thu, 22 Jan 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | S-Sale | 1,054 | $1.94K |
| Wed, 21 Jan 2026 | Barton Russell | officer: Chief Operating Officer | S-Sale | 2,315 | $4.19K |
| Wed, 21 Jan 2026 | OConnell Daniel Joseph | director, officer: Chief Executive Officer | S-Sale | 9,346 | $16.92K |
| Wed, 21 Jan 2026 | Zuga Matt | officer: CFO & Chief Business Officer | S-Sale | 2,473 | $4.48K |
| Wed, 21 Jan 2026 | Siemers Eric | officer: Chief Medical Officer | S-Sale | 2,331 | $4.2K |
| Wed, 21 Jan 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | S-Sale | 2,247 | $4.07K |
| Fri, 16 Jan 2026 | Doherty James J. | officer: President and CDO | A-Award | 166,867 | $0 |
| Tue, 20 Jan 2026 | OConnell Daniel Joseph | director, officer: Chief Executive Officer | A-Award | 299,800 | $0 |
| Fri, 16 Jan 2026 | Schacterle Amy | officer: Chief Regulatory Officer | A-Award | 84,600 | $0 |
| Fri, 16 Jan 2026 | Barton Russell | officer: Chief Operating Officer | A-Award | 84,600 | $0 |
| Fri, 16 Jan 2026 | Siemers Eric | officer: Chief Medical Officer | A-Award | 99,133 | $0 |
| Fri, 16 Jan 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | A-Award | 99,133 | $0 |
| Fri, 16 Jan 2026 | Zuga Matt | officer: CFO & Chief Business Officer | A-Award | 99,133 | $0 |
| Mon, 12 Jan 2026 | OConnell Daniel Joseph | director, officer: Chief Executive Officer | S-Sale | 5,388 | $9.32K |
| Thu, 8 Jan 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | S-Sale | 30,092 | $54.77K |
| Thu, 8 Jan 2026 | Barton Russell | officer: Chief Operating Officer | S-Sale | 3,530 | $6.57K |
| Thu, 8 Jan 2026 | Zuga Matt | officer: CFO & Chief Business Officer | S-Sale | 6,888 | $12.54K |
| Mon, 12 Jan 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | S-Sale | 8,548 | $14.62K |
| Fri, 9 Jan 2026 | OConnell Daniel Joseph | director, officer: Chief Executive Officer | S-Sale | 12,941 | $22.78K |
| Fri, 9 Jan 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | S-Sale | 5,200 | $9.15K |
| Thu, 8 Jan 2026 | OConnell Daniel Joseph | director, officer: Chief Executive Officer | S-Sale | 8,143 | $14.82K |
| Thu, 8 Jan 2026 | Meisner Derek M | officer: Chief Legal Officer & Corp Sec | S-Sale | 6,819 | $12.41K |
| Holder | Shares | % out | Change |
|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 20,992,669 | 29.0% | +0 |
| Sands Capital Alternatives, LLC | 3,720,105 | 5.1% | +0 |
| BlackRock, Inc. | 2,490,115 | 3.4% | +2,311,789 |
| Alyeska Investment Group, L.P. | 2,454,754 | 3.4% | +0 |
| FRANKLIN RESOURCES INC | 2,305,096 | 3.2% | +0 |
| ADAR1 Capital Management, LLC | 2,111,334 | 2.9% | −45,000 |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,672,072 | 2.3% | +165,795 |
| Knollwood Investment Advisory, LLC | 1,628,510 | 2.3% | +0 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,141,858 | 1.6% | +725,620 |
| Ikarian Capital, LLC | 1,053,797 | 1.5% | +0 |
| Hudson Bay Capital Management LP | 955,000 | 1.3% | −13,940 |
| Pathstone Holdings, LLC | 859,110 | 1.2% | +0 |
| RENAISSANCE TECHNOLOGIES LLC | 675,025 | 0.9% | +201,079 |
| TWO SIGMA INVESTMENTS, LP |
| 622,882 |
| 0.9% |
| +92,070 |
| STATE STREET CORP | 600,528 | 0.8% | +448,800 |
